The Lateral and Medial Pain Systems in Alzheimer’s Disease

The lateral and medial pain systems are affected differently in Alzheimer’s disease. Both the primary somatosensory cortex and some thalamic nuclei, which belong to the lateral pain system, are relatively unaffected by the histological changes that characterize Alzheimer’s disease, thus indicating that a preserved sensory-discriminative function should be expected. By contrast, the intralaminar thalamic nuclei, …